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  • Title: [Effect of prostaglandin F2alpha on the systemic and regional hemodynamics of dogs].
    Author: Flerov EV, Ismailov ShI.
    Journal: Farmakol Toksikol; 1977; 40(1):44-50. PubMed ID: 852545.
    Abstract:
    The effect of PGF2alpha on the systemic and regional hemodynamics was studied in experiments on narcotized dogs. After an intravenous injection of F2alpha (in a single dose of 10 mg/kg) aortal hypertension, tachycardia, an increased pressure in the pulmonary artery and a slightly greater cardiac output were recored. The total peripheral and pulmonary resistance was up. The left and right ventricles showed a higher activity. However, in spite of an increased myocardial contractility a short-lived deterioration in the pumping function of the heart was noted. Under the influence of PGF2alpha the coronary blood flow was becoming more intensive. PGF2alpha caused a significant reduction of the circulation rate in the femoral and superior mesenteric arteries while in the carotid and renal ones a biphasic change of the blood flow was in evidence.
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