These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Further evidence on the contribution of GABAA receptors to the GABA-mediated inhibition of medial vestibular nucleus neurones in vitro.
    Author: Hutchinson M, Smith PF, Darlington CL.
    Journal: Neuroreport; 1995 Aug 21; 6(12):1649-52. PubMed ID: 8527734.
    Abstract:
    The present study investigated the electrophysiological effects of the selective and potent GABAA receptor agonist, isoguvacine, on guinea-pig medial vestibular nucleus (MVN) neurones in brainstem slices. The results confirm that many MVN neurones have GABAA receptors and that, even at concentrations as low as 10(-8) M, GABA is capable of exerting a powerful inhibitory effect on these neurones via GABAA receptors. The finding that > 50% of neurones did not respond to isoguvacine, even at concentrations of 10(-6) M, suggested that only a specific subset of MVN neurones have GABAA receptors. Since many type I MVN neurones are believed to have postsynaptic GABAA receptors, it is possible that selective agonists such as isoguvacine may be useful in identifying type I neurones in vitro.
    [Abstract] [Full Text] [Related] [New Search]