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  • Title: Snake venom toxins. The amino acid sequences of two toxins (CM-2a and CM-3) from Naja haje annulifera (Egyptian cobra) venom.
    Author: Joubert FJ.
    Journal: Hoppe Seylers Z Physiol Chem; 1977 Mar; 358(3):377-90. PubMed ID: 852822.
    Abstract:
    Two toxins, CM-2a and CM-3, were purified from the venom of Naja haje annulifera by gel filtration on Sephadex G-50 and by ion-exchange chromatography on CM-cellulose. Whereas toxin CM-2a contains 61 amino acid residues, toxin CM-3 comprises 60 residues. Both toxins are cross-linked by four intra-chain disulphide bridges. The complete amino acid sequences of the toxins have been elucidated. The properties of the toxins were compared with those of a cytotoxin, a short neurotoxin, a long neurotoxin and an angusticeps type. The sequences of toxin CM-2a and CM-3 and some of the invariant residues do not show a high degree of similarity with those of the other toxins. The toxicities of toxins CM-2a and CM-3 are much lower than those encountered for the cytotoxin or the neurotoxins and their immunochemical properties are distinct from both the cytotoxin and the neurotoxins. They probably represent a new class of toxins.
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