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  • Title: Oxygen-derived free radicals in kidney in experimental hemorrhagic shock treated by PAF-receptor antagonist BN 52021.
    Author: Kirejczyk JK, Debek W, Dziecioł J, Chyczewski L, Makarewicz M, Nikliński J.
    Journal: Rocz Akad Med Bialymst; 1995; 40(1):77-87. PubMed ID: 8528997.
    Abstract:
    Renal damage in rat hemorrhagic shock model was assessed by estimation of the reactive oxygen metabolites generation (malondialdehyde measured as thiobarbituric acid reactive substances) and antioxidative potential (activity of Cu-, Zn- superoxide dismutase, activity of glutathione reductase and level of sulfhydryl compounds). It was found that treatment with BN 52021 (a platelet-activating factor antagonist), and polyelektrolyte solution had had a beneficial effect in comparison with both the untreated shock and shock treated by reperfusion only.
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