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  • Title: Identification of the in vivo truncation sites at the C-terminal region of alpha-A crystallin from aged bovine and human lens.
    Author: Takemoto LJ.
    Journal: Curr Eye Res; 1995 Sep; 14(9):837-41. PubMed ID: 8529423.
    Abstract:
    Total alpha-A crystallin was purified from young versus old lens, followed by digestion with cyanogen bromide. Laser desorption mass spectrometry of the C-terminal fragment demonstrated age-dependent loss of one and five amino acids from the C-terminus of alpha-A crystallin from both bovine and human lens. These results demonstrate specific peptide bonds of alpha-A crystallin are cleaved during the aging process of the normal lens. The C-terminal region is cleaved in two places between the two hydroxyl-containing amino acids present in the sequence -P-S(T)-S-.
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