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  • Title: Isolation, characterization, and precise physical localization of human CDX1, a caudal-type homeobox gene.
    Author: Bonner CA, Loftus SK, Wasmuth JJ.
    Journal: Genomics; 1995 Jul 20; 28(2):206-11. PubMed ID: 8530027.
    Abstract:
    The human CDX1 gene has been isolated from a small intestine cDNA library using a murine Cdx1 cDNA probe. The nucleotide sequence of CDX1 is 81% identical to murine Cdx1 and predicts a 265-amino-acid protein with 85% identity to the mouse protein (98% identity, including conservative amino acid changes). The CDX1 locus has been mapped to a cosmid contig from chromosome 5q31-q33, placing CDX1 approximately 100 kb distal to CSFIR. Expression of CDX1 in adults appears to be limited to the intestine and colon by Northern analysis, suggesting a possible role in the terminal differentiation of the intestine. Further analysis of CDX1 should elucidate the function of caudal-type homeobox genes in human development.
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