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  • Title: [Unilateral effective renal plasma flow measurement using one-compartment analysis of 99mTc-MAG3 and gamma-camera renography].
    Author: Oriuchi N, Tokunaga M, Suzuki H, Inoue T, Ohnishi Y, Inoue T, Endo K.
    Journal: Nihon Igaku Hoshasen Gakkai Zasshi; 1995 Sep; 55(11):757-62. PubMed ID: 8532508.
    Abstract:
    The aim of this study was to establish a simple and accurate procedure to calculate the unilateral effective renal plasma flow (ERPF) using 99mTc-MAG3 gamma-camera renographyl. Eleven patients with urological disorders were studied with 99mTc-MAG3 to calculate the renal uptake ratio (RUR), which was defined as the ratio of absorption-corrected renal counts within 1-2 min after intravenous injection to injection radioactivity measured with a gamma-camera. We assumed that 99mTc-MAG3 was distributed in the circulation, moved from the circulation to the kidneys, and was excreted solely from the kidneys. We thus adopted an one-compartment model to calculate 99mTc-MAG3 clearance (CLMAG) using RUR. Sequential p-aminohippurate (PAH) clearance study was performed as a gold standard in all the patients to compare CLMAG and PAH clearance. Obtained CLMAG correlated well with PAH clearance, and this one-compartment model seemed appropriate for describing CLMAG. Unilateral ERPF was accurately measured within two minutes after the intravenous injection of 99mTc-MAG3 in conjunction with the renal imaging study. This procedure is simple and reliable, and requires no blood or urine sampling.
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