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Title: Statistical basis for the determination of optical pathlength in tissue. Author: Arridge SR, Hiraoka M, Schweiger M. Journal: Phys Med Biol; 1995 Sep; 40(9):1539-58. PubMed ID: 8532764. Abstract: In this paper we show how to derive the mean and variance of the transilluminated signal obtained in models of light propagation in tissue, based both on a stochastic Monte Carlo method and on a deterministic diffusion approximation. The theoretical treatment of the Monte Carlo model applies only to integrated intensity measurements, whereas the diffusion approximation gives an estimator for the time-dependent case as well. We present results that show the accurate prediction of Monte Carlo statistics, and propose that the diffusion approximation is therefore a suitable mechanism for incorporating noise into modelling procedures.[Abstract] [Full Text] [Related] [New Search]