These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Macrophage stimulation activity of the polysaccharide fraction from a marine alga (Porphyra yezoensis): structure-function relationships and improved solubility.
    Author: Yoshizawa Y, Ametani A, Tsunehiro J, Nomura K, Itoh M, Fukui F, Kaminogawa S.
    Journal: Biosci Biotechnol Biochem; 1995 Oct; 59(10):1933-7. PubMed ID: 8534986.
    Abstract:
    The polysaccharide fraction from Porphyra yezoensis (PASF) has already been shown to stimulate murine phagocytic functions in vivo and in vitro [Y. Yoshizawa et al., Biosci. Biotech. Biochem., 57, 1862-1866 (1993)]. In this study, various treatments were applied to PASF to assess its structure-function relationships. Desulfation of PASF decreased in vitro macrophage-stimulation activity, while further sulfation of PASF did not change the activity. Among 7 fractions obtained by anion-exchange chromatography of PASF, stronger activity was found in the fractions having a lower or higher sulfate content than in those having a medium sulfate content. Digests of PASF with beta-agarase showed higher activity and solubility, and lower viscosity, than undigested PASF. These results indicate that the sulfate groups in PASF, probably porphyran, contributed to the macrophage stimulating activity, although a larger number of sulfate groups did not always cause stronger activity.
    [Abstract] [Full Text] [Related] [New Search]