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  • Title: Demonstration of the neutrophil granulocyte functional capacity in silicosis, using the NBT test.
    Author: Niculescu T, Cojocaru M.
    Journal: Rom J Intern Med; 1995; 33(1-2):73-6. PubMed ID: 8535355.
    Abstract:
    The functional capacity of neutrophils was studied using the NBT test in 68 patients with silicosis in various evolutive stages, comparatively with a group of 35 controls. The NBT test showed an initial increase of nonspecific cellular reactivity which decreased as the disease evolved. The results in the control group showed 9 +/- 5% NBT positive neutrophils. The highest proportion of NBT positive neutrophils (17.6 +/- 2.3, p < or = 0.05) was found in stage I of the disease and then decreased gradually with the evolution of the disease. The proportion of NBT positive neutrophils may be considered as a biochemical marker of neutrophil functionality.
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