These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: An anti-tumor necrosis factor antibody suppresses sleep in rats and rabbits.
    Author: Takahashi S, Kapás L, Fang J, Krueger JM.
    Journal: Brain Res; 1995 Sep 04; 690(2):241-4. PubMed ID: 8535843.
    Abstract:
    It is hypothesized that tumor necrosis factor (TNF) is an endogenous sleep-promoting substance. In the present experiments we studied the effects of a monoclonal anti-TNF antibody in rats and rabbits. Seven rats and 14 rabbits were implanted with electroencephalographic electrodes, a brain thermistor and an intracerebroventricular guide cannula. The animals were injected with saline, control IgG, and monoclonal hamster anti-murine-TNF antibodies (TNFab) on 3 separate days. Ten micrograms TNFab suppressed non-rapid-eye-movement sleep (NREMS) in rats. In rabbits, 2.5 micrograms TNFab did not affect sleep but decreased brain temperature; in contrast, 25 micrograms TNFab suppressed NREMS without affecting brain temperature. These results are consistent with the hypothesis that endogenous TNF plays an important role in sleep regulation.
    [Abstract] [Full Text] [Related] [New Search]