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  • Title: Translocation of BCR to chromosome 9 in a Philadelphia-negative chronic myeloid leukemia.
    Author: Brunel V, Sainty D, Costello R, Mozziconacci MJ, Simonetti J, Arnoulet C, Coignet L, Bouabdallah R, Gastaut JA, Gabert J.
    Journal: Cancer Genet Cytogenet; 1995 Nov; 85(1):82-4. PubMed ID: 8536245.
    Abstract:
    We report the case of a patient having Philadelphia-negative, bcr-abl-positive chronic myeloid leukemia. In situ hybridization showed the presence of the bcr-abl fusion on the chromosome 9 long arm in all mitoses observed. Stability of the disease was very difficult to obtain because of serious adverse effects to interferon and chemotherapy, mainly grade IV neutropenia, and a blast crisis occurred 12 months after diagnosis. Only three other patients with such presentation (Philadelphia negative, bcr-abl positive with bcr-abl fusion on the chromosome 9 long arm) have been reported, with a poor therapeutic response and outcome in two of them. Translocation of BCR to chromosome 9 may therefore have a worse prognosis than translocation of ABL to chromosome 22 in Philadelphia-negative chronic myeloid leukemia.
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