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  • Title: Synergists for retinoid in cellular differentiation of human promyelocytic leukemia cells HL-60.
    Author: Umemiya H, Kawachi E, Kagechika H, Fukasawa H, Hashimoto Y, Shudo K.
    Journal: Chem Pharm Bull (Tokyo); 1995 Oct; 43(10):1827-9. PubMed ID: 8536354.
    Abstract:
    4-[5H-2,3-(2,5-Dimethyl-2,5-hexano)-5-methyldibenzo[b, e]diazepin-11-yl]benzoic acid (4) enhanced the differentiation-inducing activity of retinoic acid (1) and of a synthetic retinoid Am80 (2) toward human promyelocytic leukemia cells HL-60, although 4 alone did not induce differentiation. The synergistic effect of 4 on the activities of retinoids was also seen in suppression of proliferation of HL-60 cells.
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