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  • Title: [Multiple perifollicular fibroma].
    Author: Yamamoto T, Katayama I, Nishioka K.
    Journal: Nihon Rinsho; 1995 Nov; 53(11):2759-63. PubMed ID: 8538040.
    Abstract:
    Perifollicular fibroma (PF) is a cutaneous hamartomatous proliferation of the pilar connective tissue sheath. It occurs predominantly on the face or neck in a solitary or multiple form. Histologically, it is characterized by a concentric arrangement of collagen fibers surrounding hair follicles. Other related proliferations include fibrofolliculoma and trichodiscoma, which are often complicated or have histological overlapping features, so they may represent the same spectrum of pilar mesodermal proliferation. Some individuals with multiple PFs have colonic polyposis, some of which develop into carcinomas, and there are suggestions of autosomal dominant inheritance. It appears that patients with multiple PFs and/or other connective tissue hamartomas may be at risk for colonic polyposis. Cutaneous signs may lead to an early discovery of digestive diseases.
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