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  • Title: Danger of amiodarone therapy and elevated inspired oxygen concentrations in mice.
    Author: Donica SK, Paulsen AW, Simpson BR, Ramsay MA, Saunders CT, Swygert TH, Tappe J.
    Journal: Am J Cardiol; 1996 Jan 01; 77(1):109-10. PubMed ID: 8540449.
    Abstract:
    Our study showed a statistically significant incidence of pulmonary edema in mice receiving amiodarone and 100% oxygen. This finding, together with a variety of clinical reports, indicates that in patients receiving amiodarone therapy, FiO2 should be maintained at the lowest possible level, consistent with adequate oxygenation.
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