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  • Title: [Excretion of 99m Tc-DISIDA through the bile ducts in the etiological diagnosis of neonatal cholestasis].
    Author: Ferretti-Cisneros MC, Fernandes MI, Galvão LC, Maciel LM, Sawamura R.
    Journal: Arq Gastroenterol; 1995; 32(2):85-90. PubMed ID: 8540806.
    Abstract:
    We evaluated 51 tests of 99mTc-DISIDA excretion by the biliary tree in patients with neonatal cholestasis. The aim of the present study was to verify the value of this test in the differentiation of this syndrome, correlating it to the clinical and laboratory data. The case studied were divided into two groups: extrahepatic biliary atresia, 26 patients (50.9%) and no-extrahepatic biliary atresia, 25 patients (49.1%). Analyzing the results, we concluded that this test had 96% sensitivity, 56% specificity, 69% positive predictive value, 93% negative predictive value and 76.5% accuracy. The accuracy of this test was only lower than that of hepatic biopsy. We conclude that the hepatobiliary scintigraphy was very useful in the definition of extrahepatic biliary atresia, with less value in the group of neonatal hepatitis, perhaps due to the delayed referral of the patients, short time of the scintigraphy study or factors related to the etiology of cholestasis itself.
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