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  • Title: Antileucoprotease in the airways and emphysema.
    Author: Dijkman JH.
    Journal: Monaldi Arch Chest Dis; 1995 Oct; 50(5):383-7. PubMed ID: 8541823.
    Abstract:
    Antileucoprotease (ALP) is a natural occurring anti-elastase, and is produced in the epithelium of the conducting airways. It is a small protein, consisting of 107 amino-acids arranged in 2 domains. The second domain carries the antiproteolytic active site, the first is responsible for antimicrobial activity. In hamsters, intratracheal installation of ALP prevents the development of emphysema after administration of elastase. The daily production of ALP is remarkably constant, even during exacerbations of COPD. In the human lung a positive correlation was found between the number of ALP-producing bronchiolar cells and small airway's disease and emphysema. ALP is able to penetrate the alveolar-capillary membrane and has a tendency to associate with elastic fibers.
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