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  • Title: Necrotizing soft tissue infections: obstacles in diagnosis.
    Author: Lille ST, Sato TT, Engrav LH, Foy H, Jurkovich GJ.
    Journal: J Am Coll Surg; 1996 Jan; 182(1):7-11. PubMed ID: 8542094.
    Abstract:
    BACKGROUND: This study was done to identify obstacles in the early diagnosis and treatment of necrotizing soft tissue infections. STUDY DESIGN: A ten-year retrospective case series was analyzed. RESULTS: Data from 29 patients were analyzed. Among patients undergoing early operation within 24 hours of admission (n = 17) there was one death (6 percent mortality rate); survivors averaged 2.9 operations per patient. By comparison, of patients with delayed operation (n = 12) three died (25 percent mortality rate) and there were 3.6 operations per patients. Positive fine-needle aspiration (FNA) of suspicious lesions, demonstrating either pus or bacteria by Gram's stain, led to early operation in 80 percent of patients tested. Patients with soft tissue gas on radiographs were more likely to undergo early operation (58 percent). Delayed operation was more common in the absence of radiographic findings. All patients admitted to nonsurgical services had delayed operations. CONCLUSIONS: Suspected necrotizing soft tissue infections require prompt surgical evaluation and early operative exploration. Early operation with definitive surgical therapy initiated within 24 hours of admission is associated with decreased mortality rates. Negative FNA findings, nondiagnostic radiographs, and admission to a nonsurgical service correlate with delay in definitive operative intervention.
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