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  • Title: Amniotic fluid cortisol in high-risk human pregnancies.
    Author: Gewolb IH, Hobbins JC, Tan SY.
    Journal: Obstet Gynecol; 1977 Apr; 49(4):466-70. PubMed ID: 854248.
    Abstract:
    Amniotic fluid cortisol (AFC) levels were measured in 76 normal and 67 high-risk human pregnancies. When compared to normal gestations, diabetic pregnancies were found to be associated with lower AFC levels, while toxemic, early Rh-sensitized, and other stressed pregnancies had higher mean cortisol values. Serially followed normal and high-risk pregnancies showed a progressive rise in AFC with increasing gestational age. Significant correlation between AFC concentrations and lecithin/sphingomyelin (L/S) ratios was noted in normal, diabetic, and toxemic gestations. These results are concordant with the hypothesis that cortisol may be involved in fetal lung development.
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