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  • Title: Genetic resistance against acute toxoplasmosis depends on the strain of Toxoplasma gondii.
    Author: Suzuki Y, Yang Q, Remington JS.
    Journal: J Parasitol; 1995 Dec; 81(6):1032-4. PubMed ID: 8544050.
    Abstract:
    The role of the strain of Toxoplasma gondii in genetic control of resistance against acute infection with T. gondii was studied with 2 strains of T. gondii, which differ in their virulence and genotype. Following peroral infection with 10 cysts of the C56 strain, C57BL/6 (H-2b) and C3H/HeN (H-2k) mice died significantly earlier than BALB/c mice (H-2d) mice, although all of the mice eventually died of acute toxoplasmosis from 10 to 23 days after infection. There was no significant difference in time to death between C57BL/6 mice and C3H/HeN mice. In peroral infection with 100 cysts of the less virulent ME49 strain, all C57BL/6 mice died of acute toxoplasmosis from 7 to 10 days after infection. C57BL/6 mice died significantly earlier following infection with the ME49 strain than with the C56 strain, whereas all C3H/HeN mice infected with the ME49 strain survived as did BALB/c mice. These results indicate that genetic control of resistance against acute infection with T. gondii differs depending on the strain of T. gondii.
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