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  • Title: Mediation of immunity to Toxoplasma gondii oocyst shedding in cats.
    Author: Davis SW, Dubey JP.
    Journal: J Parasitol; 1995 Dec; 81(6):882-6. PubMed ID: 8544058.
    Abstract:
    Immunity to Toxoplasma gondii, as measured by oocyst shedding, was studied in cats. In 3 trials, 12 3-mo-old T. gondii-free cats were fed tissue cysts of the ME-49 strain of T. gondii. All cats shed T. gondii oocysts for approximately 1 wk starting 3-5 days after ingesting tissue cysts. One cat became ill because of toxoplasmic pneumonia and was killed 17 days after inoculation. The remaining cats remained clinically normal. Approximately 3 mo after primary infection, these 11 cats (immune) and 11 age-matched or littermate uninfected cats (nonimmune) were challenged orally with tissue cysts of the ME-49 strain. In trials 1 and 3, 1 immune and 1 nonimmune cat were killed at 36 hr, 60 hr, 5 days, and 12 days after challenge and the development of T. gondii in intestines was studied histologically; in trial 2, cats were killed at 36 hr, 60 hr, and 5 days only. None of the "immune" cats shed oocysts after challenge. Asexual T. gondii types were found at 36 and 60 hr and at 5 days, indicating partial development of T. gondii in the intestine of immune cats. There were no significant differences in lymphocyte CD4+/CD8+ from spleen, popliteal, and mesenteric lymph nodes of immune cats compared to nonimmune cats.
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