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  • Title: Effects of myosin light chain kinase inhibitors on delayed rectifier potassium current in bullfrog sympathetic neurons.
    Author: Tokimasa T.
    Journal: Neurosci Lett; 1995 Sep 01; 197(1):75-7. PubMed ID: 8545061.
    Abstract:
    Actions of myosin light chain kinase inhibitors were tested on delayed rectifier potassium current (IK) in dissociated bullfrog sympathetic neurons. A microbial product, wortmannin (10 microM, extracellularly) and a synthetic peptide, SM-1 (20 microM, intracellularly) caused approximately 35 mV hyperpolarizing shift of the inactivation curve. Substitution of ATP (1.15 mM) in the pipette solution with 5'-adenylylimidodiphosphate mimicked the actions of wortmannin and SM-1. Results suggest that phosphorylation of myosin may modulate kinetics for the inactivation of IK.
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