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  • Title: Effects of cholinomimetic drugs and their antagonists injected into vertebral artery of unanaesthetized dogs.
    Author: Haranath PS, Indira G, Krishnamurthy A.
    Journal: Pharmacol Biochem Behav; 1977 Mar; 6(3):259-63. PubMed ID: 854519.
    Abstract:
    In unanaesthetized dogs, cholinomimetic drugs and their antagonists, catecholamines and 5HT were injected into vertebral artery placed in a skin loop. Acetylcholine (1 mg), pilocarpine (1-2 mg), nicotine (250-500 microng), eserine (100 microng) and neostigmine (250 microng) produced sleep apart from a few other peripheral effects. Sleep for longer periods followed injections of tubocurarine (1 mg), atropine (50 microng) and hexamethonium (500 microng). Adrenaline (50 microng) and noradrenaline (50-250 microng) did not produce significant effects on behaviour and sleep. 5HT (250-500 microng) also caused sleep.
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