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  • Title: Necrobiotic xanthogranuloma with cardiac involvement.
    Author: Umbert I, Winkelmann RK.
    Journal: Br J Dermatol; 1995 Sep; 133(3):438-43. PubMed ID: 8547001.
    Abstract:
    A patient with necrobiotic xanthogranuloma (NXG) and paraproteinaemia, who was followed-up for several years, and treated with low-dose chlorambucil, died as a result of a respiratory illness. The significant findings at autopsy were a xanthogranuloma of the spleen and giant cell myocarditis. The myocardial lesions were composed of macrophages, giant cells and lymphocytes. This finding is important because four of five known autopsied patients with NXG have had giant cell myocardial disease, and an effort at antemortem diagnosis should be made.
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