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  • Title: Marchantinquinone, isolated from Reboulia hemisphaerica, as inhibitor of lipid peroxidation and as free radical scavenger.
    Author: Ko FN, Liao CH, Wu CL.
    Journal: Chem Biol Interact; 1995 Nov 17; 98(2):131-43. PubMed ID: 8548853.
    Abstract:
    The antioxidant effect of marchantinquinone was studied using various models. Marchantinquinone inhibited Fe(2+)-induced lipid peroxidation in rat brain homogenate in a concentration-dependent manner with an IC50 15.3 +/- 2.9 microM. Marchantinquinone was less effective than alpha-tocopherol and BHT in reducing the stable free radical diphenyl-2-picrylhydrazyl (DPPH). The IC0.200 were 37.5 +/- 2.5, 9.2 +/- 1.6 and 14.5 +/- 2.5 microM, respectively. Marchantinquinone also scavenged peroxyl radical derived from 2,2'-azobis(2-amidinopropane)dihydrochloride (AAPH) in aqueous system with a stoichiometric factor of 0.9 +/- 0.1. Furthermore, it prevented conjugated-diene formation and apolipoprotein B (apo B) oxidation of LDL. However, marchantinquinone did not chelate Fe2+ or possess superoxide anion and hydroxyl radical scavenging activity. It also did not scavenge 2,2'-azobis(2,4-dimethylvaleronitrile) (AMVN)-derived peroxyl radical in hexane. These results indicate that marchantinquinone may be an effective antioxidant and can protect rat brain homogenate and LDL against oxidation.
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