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  • Title: Effect of labor analgesia with nalbuphine hydrochloride on fetal response to vibroacoustic stimulation.
    Author: Poehlmann S, Pinette M, Stubblefield P.
    Journal: J Reprod Med; 1995 Oct; 40(10):707-10. PubMed ID: 8551472.
    Abstract:
    OBJECTIVE: To evaluate the effect of labor analgesia with nalbuphine hydrochloride on the fetal response to vibroacoustic stimulation. STUDY DESIGN: The response to fetal acoustic stimulation (FAS) was recorded in 27 laboring patients before analgesia. After analgesia with 5 mg nalbuphine hydrochloride administered subcutaneously, the response to FAS was again recorded. RESULTS: No ominous fetal heart rate (FHR) patterns were observed. FAS reliably increased FHR baseline and long-term FHR variability and produced FHR accelerations. Nalbuphine hydrochloride analgesia did not produce a significant decrease in long-term FHR variability or alter FHR baseline but did reduce the number of FHR accelerations recorded. CONCLUSION: FAS-induced FHR accelerations did not differ from those observed before analgesia. Analgesia with low doses of nalbuphine did not alter fetal response to FAS, which therefore offers a means of assessing fetal well-being even in the narcotized fetus.
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