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  • Title: Ethanol-induced single-strand DNA breaks in rat brain cells.
    Author: Singh NP, Lai H, Khan A.
    Journal: Mutat Res; 1995 Dec; 345(3-4):191-6. PubMed ID: 8552140.
    Abstract:
    Male Sprague-Dawley rats were intubated with 4 g/kg body weight of ethanol (in a 20%, v/v, water solution). Brain cells were analyzed for single-strand DNA breaks at various post-ethanol administration time points using an alkaline microgel electrophoresis assay. Results showed a significant increase in single-strand DNA breaks in brain cells that peaked at approx. 4 h and returned to control level within 6 h after ethanol administration.
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