These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: The 2.0 A crystal structure of a heterotrimeric G protein.
    Author: Lambright DG, Sondek J, Bohm A, Skiba NP, Hamm HE, Sigler PB.
    Journal: Nature; 1996 Jan 25; 379(6563):311-9. PubMed ID: 8552184.
    Abstract:
    The structure of a heterotrimeric G protein reveals the mechanism of the nucleotide-dependent engagement of the alpha and beta gamma subunits that regulates their interaction with receptor and effector molecules. The interaction involves two distinct interfaces and dramatically alters the conformation of the alpha but not of the beta gamma subunits. The location of the known sites for post-translational modification and receptor coupling suggest a plausible orientation with respect to the membrane surface and an activated heptahelical receptor.
    [Abstract] [Full Text] [Related] [New Search]