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  • Title: Cancers among patients diagnosed as having diverticular disease of the colon.
    Author: Stefánsson T, Ekbom A, Sparén P, Påhlman L.
    Journal: Eur J Surg; 1995 Oct; 161(10):755-60. PubMed ID: 8555344.
    Abstract:
    OBJECTIVE: To assess the incidence of underlying malignancy in patients with a diagnosis of diverticular disease of the colon. DESIGN: Retrospective cohort study. SETTING: University hospital, Sweden. SUBJECTS: 7159 patients discharged from hospital with a first diagnosis of diverticulosis or diverticulitis in central Sweden 1965-1983. INTERVENTION: The cohort was followed up for two years for the occurrence of cancer. MAIN OUTCOME MEASURE: Cancer incidence. RESULTS: A total of 372 cancer cases were identified standard incidence ratio = 2.4; 95% confidence interval 2.2 to 2.7). Sites at excess risk during the first year were: colon and rectum, pancreas, prostate, stomach, lymphatic and haemopoietic tissue, liver and bile ducts, ovary and lung, with the highest excess risk in the left colon (standard incidence ratio = 17.8; 95% CI 12.7 to 24.1). CONCLUSION: Malignant diseases, especially colorectal cancer, are relatively common among patients with a clinical diagnosis of diverticulosis or diverticulitis of the colon. This may indicate a need for a change in current clinical practice.
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