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  • Title: [The effect of subinhibitory concentrations of quinolone and macrolide antibiotics on production of thermolabile hemolysins in Pseudomonas aeruginosa].
    Author: Hybenová D, Majtán V.
    Journal: Epidemiol Mikrobiol Imunol; 1995 Dec; 44(4):169-70. PubMed ID: 8556245.
    Abstract:
    The authors investigated the effect of subinhibitory concentrations (sub-MICs) of selected quinolones (enoxacine, nalidixic acid, norfloxacine) and macrolid antibiotics (erythromycin, roxitromycin) on the production of thermolabile haemolysin (phospholipase C) of P. aeruginosa. The activity of phospholipase C was markedly reduced by norfloxacine (more than 80%) and enoxacine (75 - 80%) in all sub-MICs. Nalidixic acid inhibited phospholipase C in 1/4 of MIC (75%). As to macrolid antibiotics the greatest inhibition was caused by erthromycin in 1/4 and 1/8 MIC (more than 90%). 1/16 MIC of roxitromycin did not influence the activity of the investigated enzyme and other tested sub-MICs caused its reduction to cca one half.
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