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  • Title: Docetaxel (Taxotere): single agent activity, development of combination treatment and reducing side-effects.
    Author: Pronk LC, Stoter G, Verweij J.
    Journal: Cancer Treat Rev; 1995 Sep; 21(5):463-78. PubMed ID: 8556719.
    Abstract:
    Docetaxel is a new semi-synthetic taxoid, which acts as an antimicrotubule agent and is now clinically available. Clinical studies of docetaxel as a single agent and in combination with other cytotoxic drugs reveals favourable response rates in a number of solid tumor types. Docetaxel appears to have great potential in advanced breast cancer as first or secondline chemotherapy. The dose-limiting toxicity is an early and short-lasting neutropenia. Fluid retention is a cumbersome, sometimes disabling, side-effect. Other side-effects are usually mild and include alopecia, myalgia, mucostitis, neuropathy, hypersensitivity reaction, nail changes and cutaneous reactions.
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