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  • Title: Bacillomycin Lc, a new antibiotic of the iturin group: isolations, structures, and antifungal activities of the congeners.
    Author: Eshita SM, Roberto NH, Beale JM, Mamiya BM, Workman RF.
    Journal: J Antibiot (Tokyo); 1995 Nov; 48(11):1240-7. PubMed ID: 8557563.
    Abstract:
    Bacillomycin Lc, a new antifungal antibiotic of the iturin class, was isolated from a strain of Bacillus subtilis as a set of five congeners. The structure as determined by chemical and spectrometric analyses has been shown to differ from that of bacillomycin L by sequence changes from aspartate-1 to asparagine-1 and from glutamine-5 to glutamate-5. The five congeners differ from each other only in the structure of the aliphatic side chain of the constituent beta-amino acid. The hydrophobicity of the beta-amino acid affects the antifungal activity of the congener, as activity increased in the order of increased congener retention on a reversed-phase HPLC column.
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