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  • Title: Effect of oral alanine loads on the serum triglycerides of oral contraceptive users and normal subjects.
    Author: Rose DP, Leklem JE, Fardal L, Baron RB, Shrago E.
    Journal: Am J Clin Nutr; 1977 May; 30(5):691-4. PubMed ID: 855811.
    Abstract:
    The effect of orally administered L-alanine loads on serum triglycerides, and plasma insulin and glucose, was studied in 23 women using an estrogen-containing oral contraceptive and 13 healthy female controls. Oral contraceptive users had significantly higher fasting serum triglycerides than the controls. Serum triglycerides concentrations udnerwent little changes in the controls after alanine ingestion, whereas the oral contraceptive users showed increases which were maintained throughout the 3-hr sampling period. The two groups had similar elevations in plasma insulin after alanine loading; the glucose concentrations were unchanged. The changes in serum triglycerides may have resulted from increased metabolism of alanine to pyruvate, and its incorporation into lipids under the stimulus of elevated insulin levels. 23 women using various combined oral contraceptive (OC) preparations were studied for the effect of oral L-alanine loads on serum triglycerides and plasma insulin and glucose levels. Fasting serum triglyceride levels were significantly (p less than .001) higher in women taking OCs than in the 13 control subjects. OC users also had significantly (p less than .001) higher serum triglyceride levels at all test times following alanine loading than controls. There were no marked differences between the preparations used. Increases in plasma insulin after alanine loading were similar for users and nonusers, while glucose concentrations were unchanged. It is suggested that the alteration in serum triglycerides may have been due to an increase metabolism of alanine to pyruvate, and its incorporation into lipids under insulin stimulus.
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