These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Cyproterone acetate: I. Microquantity releasing device of cyproterone acetate and its failure in inducing functional sterility in male rats.
    Author: Chatterjee A, Ray P, Gupta M, Pal AK, Kolay AR.
    Journal: Andrologia; 1977; 9(1):70-3. PubMed ID: 855942.
    Abstract:
    Prasad and his coworkers emphasized that microquantities of cyproterone acetate (CPA) when continuously available developed functional sterility in male rats by interfering the epididymal physiology. In our experimental rats either 2 or 3 capsules containing CPA as per the specification of Prasad were implanted subcutaneously and left for 300 and 250 days, respectively. Fertility test was made every month and it was observed that all the experimental animals were able to impregnate female rats throughout the experiment. Excepting the epididymis the weight of testes and other accessory glands did not differ from the controls in the animals which had 2 CPA capsules for 300 days; On the other hand, the animals which received 3 CPA capsules for 250 days showed significant reduction in weight of all the acessory glands including the testes. The microquantity releasing device of cyproterone acetate (CPA) and its failure in inducing functional sterility in male rats is described. 2 or 3 capsules containing CPA as per the specification of Prasad were implanted sc and left for 300 and 250 days, respectively. Monthly fertility tests revealed that all the experimental animals were able to impregnate female rats throughout the experiment. A significant decrease in weight (p less than .001) of the epididymides only was evident in those treated with 2 capsules for 300 days. However, 3 capsules for 250 days caused a significant reduction in the weight of testes (p less than .01), epididymides (p less than .001), seminal vesicles (p less than .001), prostates (p less than .01), and coagulating glands (p less than .01).
    [Abstract] [Full Text] [Related] [New Search]