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  • Title: Expression of an unusual Bw4 epitope by a subtype of HLA-B8 [B*0802].
    Author: Arnett KL, Adams EJ, Gumperz JE, Darke C, Marsh SG, Gelsthorpe K, Parham P.
    Journal: Tissue Antigens; 1995 Oct; 46(4):316-21. PubMed ID: 8560451.
    Abstract:
    The primary structure of a variant HLA-B8 antigen has been determined by cDNA cloning and sequencing. The variant, B*0802 differs, from the common B*0801 subtype at positions 77-83 of the alpha 1 helix that determine the Bw4 and Bw6 public epitopes. Whereas B*0801 has the common Bw6 motif, B*0802 has the Bw4 motif found in B*13 and B*44 allotypes. Serological analysis of B cell lines expressing B*0802 and of a B*0802 transfectant made with the HLA-A,B negative cell line 721.221 shows that B*0802 reacts with Bw4-specific antibodies, but at a level much lower than expected for Bw4 positive HLA-B allotypes.
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