These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: p59fyn-p125FAK cooperation in development of CD4+CD8+ thymocytes.
    Author: Kanazawa S, Ilić D, Hashiyama M, Noumura T, Yamamoto T, Suda T, Aizawa S.
    Journal: Blood; 1996 Feb 01; 87(3):865-70. PubMed ID: 8562954.
    Abstract:
    p59fyn is an Src family nonreceptor tyrosine kinase that has been suggested to play an important role in T-cell development and function. p125FAK is a unique nonreceptor tyrosine kinase and has been known to respond to integrin-extracellular matrix interactions. To examine their roles in thymocytes, heterozygous fak mutation was introduced into homozygous Fyn deficiency. The double mutation, but neither Fyn deficiency nor FAK heterozygosity alone, displayed impaired development of CD4+CD8+ thymocytes with atrophy of the thymic cortex, suggesting a unique cooperation between p59fyn and p125FAK in CD4+CD8+ T-cell development.
    [Abstract] [Full Text] [Related] [New Search]