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  • Title: Peripheral neuropathy in liver cirrhosis. A clinical and electrophysiological study.
    Author: Perretti A, Gentile S, Balbi P, Persico M, Caruso G.
    Journal: Ital J Gastroenterol; 1995 Sep; 27(7):349-54. PubMed ID: 8563004.
    Abstract:
    Clinical symptoms and/or signs of peripheral neuropathy were found in 17 of the 19 patients we studied with liver cirrhosis. In 16 of the 19 patients electrophysiological abnormalities were also observed. Mild-moderate alterations involved both motor and sensory fibres, with a higher incidence in the lower rather than upper limbs, and indicated a fibre loss rather than a fibre demyelination. These changes were observed in both alcoholic and non-alcoholic cirrhotics, suggesting a primary role of liver cirrhosis per se. In fact, both the clinical and electrophysiological abnormalities were related to the severity of the liver disease. A careful clinical examination could reveal the presence and extent of neuropathy in most cirrhotic patients.
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