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  • Title: [Trial to produce animal model of Alzheimer's disease by continuous infusion of beta-amyloid protein into the rat cerebral ventricle].
    Author: Nabeshima T.
    Journal: Nihon Shinkei Seishin Yakurigaku Zasshi; 1995 Oct; 15(5):411-8. PubMed ID: 8564734.
    Abstract:
    To develop an animal model of Alzheimer's disease, we investigated the toxicity of beta-amyloid protein which is a component of senile plaques in Alzheimer's disease. beta-Amyloid was infused into the cerebral ventricle of rats for 14 days using a mini-osmotic pump. The performance of habituation, water maze and passive avoidance tasks in beta-amyloid protein-treated rats was impaired. Choline acetyltransferase activity significantly decreased in the hippocampus both immediately and 2 weeks after cessation of the infusion. However, the learning impairment is recoverable 2 weeks after cessation of the infusion. Both immediately and 2 weeks after cessation of the infusion, glial fibrillary acidic protein immunoreactivity increased. Further, beta-amyloid protein altered the staining of nuclei of cells in the hippocampus only 2 weeks after cessation. These results suggest that beta-amyloid protein damages the central nervous system in vivo, and that this animal could be used as a model of Alzheimer's disease.
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