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  • Title: [Human basophil degranulation test (HBDT) in fungal allergic asthmatic patients].
    Author: Gu M, Zhang X.
    Journal: Zhonghua Jie He He Hu Xi Za Zhi; 1995 Jun; 18(3):158-60, 190. PubMed ID: 8565084.
    Abstract:
    The authors recommand the methodology of HBDT for testing fungal allergens, pH 7.6, 37 degrees C and 10 mg/ml are the most suitable experimental conditions. The positive rate of HBDT in allergic asthmatic patients is 91.7%, and correlated very well with the results of skin tests. The degranulation index (DI) in allergic asthma is significantly higher than that in normals (P < 0.001). The DI after one year's desensitization treatment with fungal allergens is markedly lowered than before (P < 0.001). The results suggest that HBDT is a simple, reliable and precise method to investigate allergens in vitro and also reflects the function of basophils in asthma.
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