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  • Title: Intercellular Ca2+ waves sustain coordinate insulin secretion in pig islets of Langerhans.
    Author: Bertuzzi F, Zacchetti D, Berra C, Socci C, Pozza G, Pontiroli AE, Grohovaz F.
    Journal: FEBS Lett; 1996 Jan 22; 379(1):21-5. PubMed ID: 8566222.
    Abstract:
    Insulin release was investigated in parallel with changes in cytosolic calcium concentration, [Ca2+]i, in pig islets stimulated by glucose. After two days in culture, glucose stimulation failed to induce insulin release, and caused limited [Ca2+]i changes in few cells. After ten days, insulin response was partially restored and [Ca2+]i recordings revealed a slow oscillatory activity of the whole islet. Slow oscillations appeared to be due to the average [Ca2+]i variations resulting from the spreading of waves throughout the islet. These waves demonstrate the reestablishment of functional cell coupling, which appears to play a critical role in insulin release.
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