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  • Title: Analysis of Staphylococcus aureus genes encoding penicillin-binding protein 4 and an ABC-type transporter.
    Author: Domanski TL, Bayles KW.
    Journal: Gene; 1995 Dec 29; 167(1-2):111-3. PubMed ID: 8566760.
    Abstract:
    A region of the Staphylococcus aureus chromosome has been isolated that contains the gene encoding penicillin-binding protein 4 (PBP4), as well as abcA, a gene that encodes a protein with strong sequence similarity to the ABC transporter family of proteins. A disruption in abcA by Campbell-type integration results in cells that display an increased resistance to methicillin and cefoxitin, two antibiotics known to interact with low-molecular-weight PBPs. Based on these observations, a potential regulatory link between these two genes is discussed.
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