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  • Title: Trisomy 13 in a case of myelofibrosis with myeloid metaplasia with early blastic transformation.
    Author: Ferrara F, Vicari L, Festa B, Di Noto R, Pane F, Sebastio L, Cimino R.
    Journal: Haematologica; 1995; 80(5):434-6. PubMed ID: 8566885.
    Abstract:
    We describe a case of early myeloid blastic transformation in a 64-year-old man suffering from myelofibrosis with myeloid metaplasia. Both chronic and blastic phase cytogenetic analysis showed trisomy 13 to be the sole chromosome aberration. A potential role for this rare abnormality in determining such an unusually poor clinical outcome is discussed.
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