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  • Title: 5q- in a case of chronic myelogenous leukemia relapsed after allogeneic bone marrow transplantation.
    Author: Soligo D, Romitti L, Bertolli V, Della Volpe A, Annaloro C, Lambertenghi Deliliers G.
    Journal: Haematologica; 1995; 80(5):437-9. PubMed ID: 8566886.
    Abstract:
    Clonal chromosome and/or hematological abnormalities typically observed in myelodysplastic syndromes (MDS) have been described with increased frequency after autologous bone marrow transplantation (BMT) for lymphoma. We report the case of a woman with chronic myelogenous leukemia (CML) allografted with her HLA-identical sibling who, 5 years after the transplant and under immunosuppressive treatment for chronic graft host disease (GVHD), suffered a cytogenetic relapse associated with a 5q- deletion in the host metaphases. These findings suggest that myelodysplastic changes, possibly related to the chemo-radiotherapy conditioning regimen, may also present after allogeneic BMT.
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