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  • Title: Cytochrome c oxidase subunit VIIa liver isoform. Characterization and identification of promoter elements in the bovine gene.
    Author: Seelan RS, Gopalakrishnan L, Scarpulla RC, Grossman LI.
    Journal: J Biol Chem; 1996 Jan 26; 271(4):2112-20. PubMed ID: 8567667.
    Abstract:
    Cytochrome c oxidase subunit VIIa is specified by two nuclear genes, one (COX7AH) producing a heart/muscle-specific isoform and the other (COX7AL) a form expressed in all tissues. We have isolated both genes to examine their transcriptional regulation. Here, we characterize the core promoter of COX7AL and show that a 92-base pair region flanking the 5'-end promotes most of the activity of this gene. The 92-bp basal promoter contains sites for the nuclear respiratory factors NRF-1 and NRF-2, which have been shown to contribute to the transcription of a number of nuclear genes involved in mitochondrial respiratory activity, and also at least four Sp1 motifs. We show that both the NRF-1 and NRF-2 binding sites are functional in COX7AL and present evidence suggesting that interaction between the NRF-1 site and an upstream element contributes to expression.
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