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  • Title: Simultaneous determination of anticonvulsant drugs by gas-liquid chromatography.
    Author: Hill RE, Latham AN.
    Journal: J Chromatogr; 1977 Jan 21; 131():341-6. PubMed ID: 856856.
    Abstract:
    A quantitative gas-liquid chromatographic method for the determination of blood levels of ethosuximide, phenobarbitone, primidone and diphenylhydantoin is described. All four compounds are determined using 1 ml of serum. A simple, direct extraction technique is employed. Ethosuximide is analysed without derivatization. Subsequent flash alkylation with trimethylanilinium hydroxide allows the simultaneous determination of phenobarbitone, primidone, and diphenylhydantoin.
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