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  • Title: Studies of rifamycin production by Amycolatopsis mediterranei cells immobilized on glass wool.
    Author: Abu-Shady MR, el-Diwany AI, Farid MA, el-Enshasy HA.
    Journal: J Basic Microbiol; 1995; 35(5):279-84. PubMed ID: 8568638.
    Abstract:
    Cells of Amycolatopsis mediterranei CBS 42575 were immobilized on glass wool for the production of rifamycins B and SV. Glass wool (CORNING type) of 8 microns in diameter has a better entrapment capacity for microbial cells of microorganism than the other types of glass wool used. The most suitable amount of glass wool was 0.8 g/50 ml. The best initial cell concentration used as inoculum was 40 mg cells/50 ml. Repeated batch production of rifamycins by immobilized cells on glass wool was carried out for 6 repeated batches. The results showed that reduction of batch time from 96 h to 48 h does not decrease rifamycin production by immobilized cells.
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