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  • Title: Antigenicity of cholera toxoid in humans.
    Author: Germanier R, Fürer E, Varallyay S, Inderbitzin TM.
    Journal: J Infect Dis; 1977 Apr; 135(4):512-6. PubMed ID: 856918.
    Abstract:
    A cholera toxoid was produced by heating of a purified cholera toxin and treatment of the resulting toxoid procholeragenoid with a formaldehyde solution. When given subcutaneously and intramuscularly to volunteers in doses of 3-100 microng, the toxoid produced no noteworthy side effects, but the injections produced a dose-dependent rise in level of toxin-neutralizing antibodies in serum. Administration of toxoid in combination with whole-cell vaccine induced antitoxin levels that seemed to be higher than those induced by toxoid alone, but statistical analysis revealed a significant difference only between titers after administration of 10 microng of toxoid alone and those after administration of 10 microng of toxoid in combination with whole-cell vaccine.
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