These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Regulation of the expression of HLA class I genes in human trophoblasts].
    Author: Le Bouteiller P.
    Journal: Pathol Biol (Paris); 1995 Sep; 43(7):628-35. PubMed ID: 8570269.
    Abstract:
    This article presents an overview of the more recent data dealing with the constitutive expression of classical HLA-A, -B, -C and nonclassical HLA-E, -F, -G class I genes in the different trophoblast cell subpopulations that constitute the materno-fetal interface during human pregnancy. Although transcribed, classical HLA class I genes are never expressed as membrane-bound products in any of the trophoblast cell subpopulations. On the contrary, HLA-G is expressed at the cell surface of extravillous cytotrophoblast cells from first trimester placenta, suggesting that it may play a role in the maternal tolerance against the fetal allograft. Molecular regulatory mechanisms that may control such differential expression of classical and nonclassical class I molecules, according to the cell type, state of differentiation and stage of gestation are also examined. They may operate at the levels of transcription (cis- and/or trans-acting mechanisms), translation and/or transport of HLA class I heavy chains to the cell surface.
    [Abstract] [Full Text] [Related] [New Search]