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  • Title: [A case of fish tape-worm infection treated with paromomycin and an observation on its mode of action. II. With special reference to aminosidine (author's transl)].
    Author: Kanazawa Y.
    Journal: Jpn J Antibiot; 1977 Feb; 30(2):182-4. PubMed ID: 857058.
    Abstract:
    A female adult suffering from fish tape-worm infection was successfully treated with a single oral administration of 4,000 mg aminosidine, a paromomycin. The drug concentration in the segments of the worm removed were as high as 600 mg/ml or more, meanwhile, serum level and urinary recovery in the patient were very low. Consequently, it was presumed that some acute effect, such as neuro-muscular toxicity, of the drug, which was well absorbed into parasite, but ill-absorbed from the gastrointestinal tract of human, is one of the mode of antihelminthic activity, in this case.
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