These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Changes in the picture of chronic diseases on long-term hemodialysis treatment].
    Author: von Appen K, Ivanovich P, Klinkmann H, Stetsiuk E.
    Journal: Urol Nefrol (Mosk); 1995; (5):25-7. PubMed ID: 8571479.
    Abstract:
    New data published in the literature provided evidence for appearance of an unknown variant of amyloidosis recorded in patients with a 5-15-year history of hemodialysis. Such amyloidosis may result from high blood levels of beta-2-microglobulin unremovable at standard hemodialysis. Even highly permeable membranes which permit beta-2-microglobulin penetration fail to produce negative balance of this metabolite as the procedure stimulates leukocyte activity and, consequently, beta-2-microglobulin production. In spite of the fact that contact of the blood with synthetic materials during hemodialysis is not longer than 3-5 hours, blood elements and endothelial cell metabolism, homeostasis undergo serious alterations. These effects of biocompatibility provoke the condition of enhanced activation similar to chronic inflammation. Thus, we deal with a new phenomenon in the field of hemodialysis. The efforts of investigators should be aimed at studying long-term adaptation of the body which rings atypical picture of chronic diseases.
    [Abstract] [Full Text] [Related] [New Search]